Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.

Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.

The transcription factors SCL/Tal-1 and AML1/Runx1 control the generation of pluripotent hematopoietic stem cells (pHSC) and, thereby, primitive and definitive hematopoiesis, during embryonic development of the mouse from mesoderm. Thus, Runx1-deficient mice generate primitive, but not definitive he...

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Bibliographic Details
Main Authors: Julia Tornack, Katharina Seiler, Andreas Grützkau, Joachim R Grün, Masafumi Onodera, Fritz Melchers, Motokazu Tsuneto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3726448?pdf=render

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http://europepmc.org/articles/PMC3726448?pdf=render

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