Impact of SGLT2 Inhibitors on Heart Failure: From Pathophysiology to Clinical Effects

Impact of SGLT2 Inhibitors on Heart Failure: From Pathophysiology to Clinical Effects

Heart failure (HF) affects up to over 20% of patients with type 2 diabetes (T2DM), even more in the elderly. Although, in T2DM, both hyperglycemia and the proinflammatory status induced by insulin resistance are crucial in cardiac function impairment, SGLT2i cardioprotective mechanisms against HF ar...

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Bibliographic Details
Main Authors: Giuseppe Palmiero, Arturo Cesaro, Erica Vetrano, Pia Clara Pafundi, Raffaele Galiero, Alfredo Caturano, Elisabetta Moscarella, Felice Gragnano, Teresa Salvatore, Luca Rinaldi, Paolo Calabrò, Ferdinando Carlo Sasso
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
SGLT2 inhibitors
heart failure
pathophysiology
type 2 diabetes
cardiovascular risk
Online Access:https://www.mdpi.com/1422-0067/22/11/5863

Internet

https://www.mdpi.com/1422-0067/22/11/5863

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