Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis

Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis

Abstract Background Single rare cell characterization represents a new scientific front in personalized therapy. Imaging mass cytometry (IMC) may be able to address all these questions by combining the power of MS-CyTOF and microscopy. Methods We have investigated this IMC method using < 100 to u...

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Bibliographic Details
Main Authors: Izhar S. Batth, Qing Meng, Qi Wang, Keila E. Torres, Jared Burks, Jing Wang, Richard Gorlick, Shulin Li
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Cancer
Subjects:
Imaging mass cytometry (IMC)
Circulating tumor cells (CTCs)
T-distributed stochastic neighbor embedding (t-SNE)
Patient-derived xenograft (PDX)
Copy number variations (CNV)
Fluorescence associated cell-sorting (FACS)
Online Access:http://link.springer.com/article/10.1186/s12885-020-07203-7

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http://link.springer.com/article/10.1186/s12885-020-07203-7

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