EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation
Abstract Background Low concentrations of tumor necrosis factor-alpha (TNF-α) and its receptor TNFR2 are both reported to promote osteogenic differentiation of osteoblast precursor cells. Moreover, low concentrations of TNF-α up-regulate the expression of EphB4. However, the molecular mechanisms und...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-04-01
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Series: | BMC Molecular and Cell Biology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12860-020-00273-2 |