BTLA/HVEM Axis Induces NK Cell Immunosuppression and Poor Outcome in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is characterized by progressive immunosuppression and diminished cancer immunosurveillance. Immune checkpoint blockade (ICB)-based therapies, a major breakthrough against cancer, have emerged as a powerful tool to reinvigorate antitumor responses. Herein, we analyz...

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Bibliographic Details
Main Authors: Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, Ana P. Gonzalez-Rodriguez, Angel R. Payer, Esther González-García, Alejandro López-Soto, Segundo Gonzalez
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
CLL
Online Access:https://www.mdpi.com/2072-6694/13/8/1766