Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

Doxorubicin is used extensively for chemotherapy of diverse types of cancer, yet the mechanism through which it inhibits proliferation of cancer cells remains unclear. Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates CREB3L1, a transcription factor sy...

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Bibliographic Details
Main Authors: Bray Denard, Ching Lee, Jin Ye
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2012-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/00090