Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells

The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cells intermingled with Paneth cells at the base of crypts. These crypt base stem cells exclusively express Lgr5 and require Wnt3 or, in its absence, Wnt2b. However, the Fri...

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Bibliographic Details
Main Authors: Dustin J. Flanagan, Toby J. Phesse, Nick Barker, Renate H.M. Schwab, Nancy Amin, Jordane Malaterre, Daniel E. Stange, Cameron J. Nowell, Scott A. Currie, Jarel T.S. Saw, Eva Beuchert, Robert G. Ramsay, Owen J. Sansom, Matthias Ernst, Hans Clevers, Elizabeth Vincan
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000971

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