Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge

Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge

Abstract Modified Vaccinia Ankara (MVA) was recently approved as a smallpox vaccine. Variola is transmitted by respiratory droplets and MVA immunization by skin scarification (s.s.) protected mice far more effectively against lethal respiratory challenge with vaccinia virus (VACV) than any other rou...

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Bibliographic Details
Main Authors: Youdong Pan, Luzheng Liu, Tian Tian, Jingxia Zhao, Chang Ook Park, Serena Y. Lofftus, Claire A. Stingley, Yu Yan, Shenglin Mei, Xing Liu, Thomas S. Kupper
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-020-00265-5

Internet

https://doi.org/10.1038/s41541-020-00265-5

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