Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration

Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration

Recently developed therapeutic approaches for the treatment of Huntington's disease (HD) require preclinical testing in large animal models. The minipig is a suitable experimental animal because of its large gyrencephalic brain, body weight of 70-100 kg, long lifespan, and anatomical, physiolog...

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Bibliographic Details
Main Authors: Taras Ardan, Monika Baxa, Božena Levinská, Miroslava Sedláčková, The Duong Nguyen, Jiří Klíma, Štefan Juhás, Jana Juhásová, Petra Šmatlíková, Petra Vochozková, Jan Motlík, Zdenka Ellederová
Format: Article
Language:English
Published: The Company of Biologists 2020-02-01
Series:Disease Models & Mechanisms
Subjects:
large animal model
tghd
brain
huntingtin
neuropathology
Online Access:http://dmm.biologists.org/content/13/2/dmm041319

Internet

http://dmm.biologists.org/content/13/2/dmm041319

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