Evaluation of methodologies to determine the effect of specific active immunotherapy on VEGF levels in phase I clinical trial patients with advanced solid tumors

Evaluation of methodologies to determine the effect of specific active immunotherapy on VEGF levels in phase I clinical trial patients with advanced solid tumors

Two phase I clinical trials were conducted to evaluate, among other parameters, the humoral response elicited by a vascular endothelial growth factor (VEGF)-based therapeutic vaccine in cancer patients with advanced solid tumors. VEGF reduction was studied using an indirect methodology named as “Pla...

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Bibliographic Details
Main Authors: Javier Sánchez Ramírez, Mónica Bequet-Romero, Yanelys Morera Díaz, Francisco Hernández-Bernal, Ana de la Torre Santos, Katty-Hind Selman-Housein Bernal, Yenima Martín Bauta, Cimara H. Bermúdez Badell, Miladys Limonta Fernández, Marta Ayala Avila
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Heliyon
Subjects:
Cancer research
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018317699

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http://www.sciencedirect.com/science/article/pii/S2405844018317699

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