Astrocytes constitute the major TNF-α-producing cell population in the infarct cortex in dMCAO rats receiving intravenous MSC infusion

Astrocytes constitute the major TNF-α-producing cell population in the infarct cortex in dMCAO rats receiving intravenous MSC infusion

Recent studies report that inhibiting TNF-α might be a novel therapeutic strategy for managing brain ischemia. Our previous study reported that mesenchymal stem cell (MSC) transplantation could suppress TNF-α level in both serum and brain. However, the cell type(s) that contribute to the production...

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Bibliographic Details
Main Authors: Yunqian Guan, Ren Wang, Xiaobo Li, Haiqiang Zou, Wenxiu Yu, Zhaohui Liang, Lei Li, Ling Chen, Liping Zhou, Zhiguo Chen
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tumor Necrosis Factor-α
Cerebral Ischemia
Mesenchymal Stem Cell transplantation
Microglia
Astrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221007538

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http://www.sciencedirect.com/science/article/pii/S0753332221007538

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