Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG

Immunization With Mycobacterium tuberculosis Antigens Encapsulated in Phosphatidylserine Liposomes Improves Protection Afforded by BCG

Liposomes have been long considered as a vaccine delivery system but this technology remains to be fully utilized. Here, we describe a novel liposome-based subunit vaccine formulation for tuberculosis (TB) based on phosphatidylserine encapsulating two prominent TB antigens, Ag85B, and ESAT-6. We sho...

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Bibliographic Details
Main Authors: Gil R. Diogo, Peter Hart, Alastair Copland, Mi-Young Kim, Andy C. Tran, Noemi Poerio, Mahavir Singh, Matthew J. Paul, Maurizio Fraziano, Rajko Reljic
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
liposomes
tuberculosis
vaccine
BCG
immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01349/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01349/full

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