IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence.

IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence.

IL-10 is an anti-inflammatory cytokine that regulates the extent of host immunity to infection by exerting suppressive effects on different cell types. Herpes viruses induce IL-10 to modulate the virus-host balance towards their own benefit, resulting in prolonged virus persistence. To define the ce...

Full description

Bibliographic Details
Main Authors: Sanja Mandaric, Senta M Walton, Thomas Rülicke, Kirsten Richter, Mathilde J H Girard-Madoux, Björn E Clausen, Antonija Zurunic, Masahito Kamanaka, Richard A Flavell, Stipan Jonjic, Annette Oxenius
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22876184/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22876184/pdf/?tool=EBI

Similar Items