Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors

Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors

Background: Dysregulated lipid metabolism is emerging as a hallmark in several malignancies, including ovarian cancer (OC). Specifically, metastatic OC is highly dependent on lipid-rich omentum. We aimed to investigate the therapeutic value of targeting lipid metabolism in OC. For this purpose, we s...

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Bibliographic Details
Main Authors: Dafne Jacome Sanz, Juuli Raivola, Hanna Karvonen, Mariliina Arjama, Harlan Barker, Astrid Murumägi, Daniela Ungureanu
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
omentum
ovarian cancers
PCSK9
drug testing
mTOR
metabolism
Online Access:https://www.mdpi.com/2072-6694/13/15/3727

Internet

https://www.mdpi.com/2072-6694/13/15/3727

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