Desensitization, trafficking and resensitization of the pituitary thyrotropin-releasing hormone receptor
The pituitary receptor for thyrotropin-releasing hormone (TRH) is a calcium-mobilizing G protein-coupled receptor (GPCR) that signals through Gq/11, elevating calcium and activating protein kinase C. TRH receptor signaling is quickly desensitized as a consequence of receptor phosphorylation, arresti...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-12-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00180/full |