Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila

Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila

Unpaired ligands are secreted signals that act via a GP130-like receptor, domeless, to activate JAK/STAT signalling in Drosophila. Like many mammalian cytokines, unpaireds can be activated by infection and other stresses and can promote insulin resistance in target tissues. However, the importance o...

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Bibliographic Details
Main Authors: Katrin Kierdorf, Fabian Hersperger, Jessica Sharrock, Crystal M Vincent, Pinar Ustaoglu, Jiawen Dou, Attila Gyoergy, Olaf Groß, Daria E Siekhaus, Marc S Dionne
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
muscle
insulin/AKT
JAK/STAT
macrophages
metabolism
plasmatocytes
Online Access:https://elifesciences.org/articles/51595

Internet

https://elifesciences.org/articles/51595

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