Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak.

Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak.

Clinical and model studies indicate that low nitric oxide (NO) bioavailability due in part to profound hypoargininemia contributes to cerebral malaria (CM) pathogenesis. Protection against CM pathogenesis may be achieved by altering the diet before infection with Plasmodium falciparum infection (nut...

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Bibliographic Details
Main Authors: Irene Gramaglia, Joyce Velez, Yu-Sun Chang, Wilson Caparros-Wanderley, Valery Combes, Georges Grau, Monique F Stins, Henri C van der Heyde
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213428

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https://doi.org/10.1371/journal.pone.0213428

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