Matured Tolerogenic Dendritic Cells Effectively Inhibit Autoantigen Specific CD4+ T Cells in a Murine Arthritis Model

Matured Tolerogenic Dendritic Cells Effectively Inhibit Autoantigen Specific CD4+ T Cells in a Murine Arthritis Model

Tolerogenic dendritic cells (tolDCs) are a promising treatment modality for diseases caused by a breach in immune tolerance, such as rheumatoid arthritis. Current medication for these diseases is directed toward symptom suppression but no real cure is available yet. TolDC-based therapy aims to resto...

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Bibliographic Details
Main Authors: Manon A. A. Jansen, Rachel Spiering, Irene S. Ludwig, Willem van Eden, Catharien M. U. Hilkens, Femke Broere
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
arthritis
tolDCs
CD4+ T cell
immune modulation
immune tolerance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02068/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02068/full

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