The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

Summary: T regulatory (Treg) cells are crucial to maintain immune tolerance and repress antitumor immunity, but the mechanisms governing their cellular redox homeostasis remain elusive. We report that glutathione peroxidase 4 (Gpx4) prevents Treg cells from lipid peroxidation and ferroptosis in regu...

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Bibliographic Details
Main Authors: Chengxian Xu, Shaogang Sun, Travis Johnson, Rong Qi, Siyuan Zhang, Jie Zhang, Kai Yang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
Treg cells
Gpx4
lipid peroxidation
ferroptosis
TCR stimulation
mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721005945

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http://www.sciencedirect.com/science/article/pii/S2211124721005945

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