Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants

Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants

More effective treatments to reduce pathological alcohol drinking are needed. The glutamatergic system and the NMDA receptor (NMDAR), in particular, are implicated in behavioral and molecular consequences of chronic alcohol use, making the NMDAR a promising target for novel pharmacotherapeutics. Eth...

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Bibliographic Details
Main Authors: Summer L. Thompson, Carol A. Gianessi, Stephanie S. O'Malley, Dana A. Cavallo, Julia M. Shi, Jeanette M. Tetrault, Kelly S. DeMartini, Ralitza Gueorguieva, Brian Pittman, John H. Krystal, Jane R. Taylor, Suchitra Krishnan-Sarin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Psychiatry
Subjects:
saracatinib
AZD0530
Fyn kinase
alcohol use disorders
alcohol habit
NMDA receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.709559/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2021.709559/full

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