Evolutionary conservation of drug action on lipoprotein metabolism-related targetss⃞

Evolutionary conservation of drug action on lipoprotein metabolism-related targetss⃞

Genetic analysis has shown that the slower than normal rhythmic defecation behavior of the clk-1 mutants of Caenorhabditis elegans is the result of altered lipoprotein metabolism. We show here that this phenotype can be suppressed by drugs that affect lipoprotein metabolism, including drugs that aff...

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Bibliographic Details
Main Authors: Abdelmadjid K. Hihi, Marie-Claude Beauchamp, Robyn Branicky, Annick Desjardins, Isabel Casanova, Marie-Pierre Guimond, Melissa Carroll, Melanie Ethier, Irenej Kianicka, Kevin McBride, Siegfried Hekimi
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Lipid Research
Subjects:
Caenorhabditis elegans
drug discovery
dyslipidemia
clk-1
reverse cholesterol transport
high density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520428822

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http://www.sciencedirect.com/science/article/pii/S0022227520428822

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