Therapeutic Potential of TNFα and IL1β Blockade for CRS/ICANS in CAR-T Therapy via Ameliorating Endothelial Activation

Therapeutic Potential of TNFα and IL1β Blockade for CRS/ICANS in CAR-T Therapy via Ameliorating Endothelial Activation

Severe cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) strongly hampered the broad clinical applicability of chimeric antigen receptor T cell (CAR-T) therapy. Vascular endothelial activation has been suggested to contribute to the development of CRS...

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Bibliographic Details
Main Authors: Yunshuo Chen, Ranran Li, Siqi Shang, Xuejiao Yang, Lei Li, Wenbo Wang, Yueying Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
coagulation
leakage
inflammatory response
cytokine release
CAR-T immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.623610/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.623610/full

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