Antitumoral effects of γCdcPLI, a PLA2 inhibitor from Crotalus durissus collilineatus via PI3K/Akt pathway on MDA-MB-231 breast cancer cell

Antitumoral effects of γCdcPLI, a PLA2 inhibitor from Crotalus durissus collilineatus via PI3K/Akt pathway on MDA-MB-231 breast cancer cell

Abstract Phospholipases A2 (PLA2s) overexpression is closely associated with the malignant potential of breast cancers. Here, we showed for the first the antitumoral effects of γCdcPLI, a PLA2 inhibitor from Crotalus durissus collilineatus via PI3K/Akt pathway on MDA-MB-231 cell. Firstly, γCdcPLI wa...

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Bibliographic Details
Main Authors: Sarah N. C. Gimenes, Daiana S. Lopes, Patrícia T. Alves, Fernanda V. P. V. Azevedo, Lara Vecchi, Luiz R. Goulart, Thais C. S. Rodrigues, André L. Q. Santos, Vera L. de C. Brites, Thaise L. Teixeira, Cláudio V. da Silva, Matheus H. Dias, Samuel C. Teixeira, Renata S. Rodrigues, Kelly A. G. Yoneyama, Ricardo A. Oliveira, Veridiana de M. Rodrigues
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07082-2

Internet

https://doi.org/10.1038/s41598-017-07082-2

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