PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation.

PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation.

PARP inhibition can induce anti-neoplastic effects when used as monotherapy or in combination with chemo- or radiotherapy in various tumor settings; however, the basis for the anti-metastasic activities resulting from PARP inhibition remains unknown. PARP inhibitors may also act as modulators of tum...

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Bibliographic Details
Main Authors: María Isabel Rodríguez, Andreína Peralta-Leal, Francisco O'Valle, José Manuel Rodriguez-Vargas, Ariannys Gonzalez-Flores, Jara Majuelos-Melguizo, Laura López, Santiago Serrano, Antonio García de Herreros, Juan Carlos Rodríguez-Manzaneque, Rubén Fernández, Raimundo G Del Moral, José Mariano de Almodóvar, F Javier Oliver
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3681683?pdf=render

Internet

http://europepmc.org/articles/PMC3681683?pdf=render

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