Gastrointestinal Distension by Pectin-Containing Carbonated Solution Suppresses Food Intake and Enhances Glucose Tolerance via GLP-1 Secretion and Vagal Afferent Activation

Gastrointestinal Distension by Pectin-Containing Carbonated Solution Suppresses Food Intake and Enhances Glucose Tolerance via GLP-1 Secretion and Vagal Afferent Activation

Diet-induced gastrointestinal distension is known to evoke satiation and suppress postprandial hyperglycemia; however, the underlying mechanisms remain poorly understood. This study explored how gastrointestinal distension regulates energy homeostasis by using inflating stomach formulation (ISF), th...

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Bibliographic Details
Main Authors: Kento Ohbayashi, Yukiko Oyama, Chiharu Yamaguchi, Toshiki Asano, Toshihiko Yada, Yusaku Iwasaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Endocrinology
Subjects:
gastric distension
intestinal distension
glucagon-like peptide-1
vagal afferents
food intake
insulin sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.676869/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.676869/full

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