Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2′-O-Methylations in RNA by RiboMethSeq

Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2′-O-Methylations in RNA by RiboMethSeq

A major trend in the epitranscriptomics field over the last 5 years has been the high-throughput analysis of RNA modifications by a combination of specific chemical treatment(s), followed by library preparation and deep sequencing. Multiple protocols have been described for several important RNA mod...

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Bibliographic Details
Main Authors: Florian Pichot, Virginie Marchand, Lilia Ayadi, Valérie Bourguignon-Igel, Mark Helm, Yuri Motorin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Genetics
Subjects:
2′-O-methylation
RNA
ribose methylation
high-throughput sequencing
bioinformatic pipeline
receiver operating characteristic
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00038/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.00038/full

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