SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an important role in maintaining active replication and prote...

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Bibliographic Details
Main Authors: Julie Rageul, Jennifer J. Park, Ping Ping Zeng, Eun-A Lee, Jihyeon Yang, Sunyoung Hwang, Natalie Lo, Alexandra S. Weinheimer, Orlando D. Schärer, Jung-Eun Yeo, Hyungjin Kim
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19162-5

Internet

https://doi.org/10.1038/s41467-020-19162-5

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