On the Design of Broad-Based Neuropsychological Test Batteries to Assess the Cognitive Abilities of Individuals with Down Syndrome in the Context of Clinical Trials

On the Design of Broad-Based Neuropsychological Test Batteries to Assess the Cognitive Abilities of Individuals with Down Syndrome in the Context of Clinical Trials

Down syndrome (DS) is the most common genetically-defined cause of intellectual disability. Neurodevelopmental deficits displayed by individuals with DS are generally global, however, disproportionate deficits in cognitive processes that depend heavily on the hippocampus and prefrontal cortex are al...

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Bibliographic Details
Main Authors: Ines A. Basten, Richard Boada, Hudson G. Taylor, Katherine Koenig, Veridiana L. Barrionuevo, Ana C. Brandão, Alberto C. S. Costa
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Brain Sciences
Subjects:
down syndrome
hippocampal deficits
executive function
episodic memory
working memory
neurocognitive phenotype
memantine
NMDA receptor
Alzheimer’s disease
Online Access:https://www.mdpi.com/2076-3425/8/12/205

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https://www.mdpi.com/2076-3425/8/12/205

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