Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway

Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway

Transforming growth factor-β1 (TGF-β1) is a crucial factor implicated in the development of renal inflammation and tubulointerstitial fibrosis (TIF). The cytokine interleukin 22 (IL-22) was previously reported to involve in the pathogenesis of chronic inflammatory diseases, however recent studies sh...

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Bibliographic Details
Main Authors: Rong Tang, Xiangcheng Xiao, Yang Lu, Huihui Li, Qiaoling Zhou, Patrick Kwadwo Nuro-Gyina, Xia Li
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Renal Failure
Subjects:
tgf-β1
renal tubular cell
inflammation
fibrosis
il-22
notch1 pathway
Online Access:http://dx.doi.org/10.1080/0886022X.2020.1753538

Internet

http://dx.doi.org/10.1080/0886022X.2020.1753538

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