Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells

Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells

The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic potential in type 2 diabetes. Here, we have evaluated how different factors comb...

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Bibliographic Details
Main Authors: Zijian Fang, Shiqian Chen, Yusman Manchanda, Stavroula Bitsi, Philip Pickford, Alessia David, Maria M. Shchepinova, Ivan R. Corrêa Jr, David J. Hodson, Johannes Broichhagen, Edward W. Tate, Frank Reimann, Victoria Salem, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
glucagon-like peptide-1
exendin-4
trafficking
biased agonism
degradation
endothelin converting enzyme-1
Online Access:https://www.mdpi.com/1422-0067/21/21/8404

Internet

https://www.mdpi.com/1422-0067/21/21/8404

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