Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes

Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes

Introduction Pancreatic duodenum homeobox 1 (Pdx1) expression is crucial for pancreatic organogenesis and is a key regulator of insulin gene expression. Hairy and enhancer of split 1 (Hes1) controls tissue morphogenesis by maintaining undifferentiated cells. Hes1 encodes a basic helix loop helix (bH...

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Main Authors: Eiji Kobayashi, Masaki Nagaya, Koki Hasegawa, Masahito Watanabe, Kazuaki Nakano, Kazutoshi Okamoto, Takeshi Yamada, Ayuko Uchikura, Kenji Osafune, Harumasa Yokota, Taiji Nagaoka, Hitomi Matsunari, Kazuhiro Umeyama, Hiromitsu Nakauchi, Hiroshi Nagashima
Format: Article
Language:English
Published: BMJ Publishing Group 2020-12-01
Series:BMJ Open Diabetes Research & Care
Online Access:https://drc.bmj.com/content/8/2/e001792.full

Internet

https://drc.bmj.com/content/8/2/e001792.full

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