Homozygous Deletion in the Coding Sequence of the c-mer Gene in RCS Rats Unravels General Mechanisms of Physiological Cell Adhesion and Apoptosis

Homozygous Deletion in the Coding Sequence of the c-mer Gene in RCS Rats Unravels General Mechanisms of Physiological Cell Adhesion and Apoptosis

The RCS rat presents an autosomal recessive retinal pigment epithelium dystrophy characterized by the outer segments of photoreceptors being phagocytosis-deficient. A systematic genetic study allowed us to restrict the interval containing the rdy locus to that between the markers D3Mit13 and D3Rat25...

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Bibliographic Details
Main Authors: Emeline Nandrot, Eric M Dufour, Alexandra C Provost, Marie O Péquignot, Sébastien Bonnel, Karı̈n Gogat, Dominique Marchant, Christelle Rouillac, Bertille Sépulchre de Condé, Marie-Thérèse Bihoreau, Cindi Shaver, Jean-Louis Dufier, Cécile Marsac, Mark Lathrop, Maurice Menasche, Marc M Abitbol
Format: Article
Language:English
Published: Elsevier 2000-12-01
Series:Neurobiology of Disease
Subjects:
RCS rats
retinal pigment epithelium
macrophages
phagocytosis
c-mer
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100903280

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http://www.sciencedirect.com/science/article/pii/S0969996100903280

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