Conazole fungicides inhibit Leydig cell testosterone secretion and androgen receptor activation in vitro

Conazole fungicides inhibit Leydig cell testosterone secretion and androgen receptor activation in vitro

Conazole fungicides are widely used in agriculture despite their suspected endocrine disrupting properties. In this study, the potential (anti-)androgenic effects of ten conazoles were assessed and mutually compared with existing data. Effects of cyproconazole (CYPRO), fluconazole (FLUC), flusilazol...

Full description

Bibliographic Details
Main Authors: Maarke J.E. Roelofs, A. Roberto Temming, Aldert H. Piersma, Martin van den Berg, Majorie B.M. van Duursen
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Toxicology Reports
Subjects:
Androgen receptor (AR)
Conazole fungicides
Endocrine disrupting chemicals (EDCs)
MA-10 Leydig cells
Spermatogenesis
Testosterone (T)
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750014000262

Internet

http://www.sciencedirect.com/science/article/pii/S2214750014000262

Similar Items