Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains

Abstract Human protein tyrosine phosphatase non-receptor type 4 (PTPN4) has been shown to prevent cell death. The active form of human PTPN4 consists of two globular domains, a PDZ (PSD-95/Dlg/ZO-1) domain and a phosphatase domain, tethered by a flexible linker. Targeting its PDZ domain abrogates th...

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Bibliographic Details
Main Authors: Célia Caillet-Saguy, Angelo Toto, Raphael Guerois, Pierre Maisonneuve, Eva di Silvio, Kristi Sawyer, Stefano Gianni, Nicolas Wolff
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08193-6

Internet

https://doi.org/10.1038/s41598-017-08193-6

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