The Expression of Toll-Like Receptor 4 mRNA in PBMCs Is Upregulated in Smokers and Decreases Upon Smoking Cessation

The Expression of Toll-Like Receptor 4 mRNA in PBMCs Is Upregulated in Smokers and Decreases Upon Smoking Cessation

BackgroundStudies have shown in vitro that cigarette smoke condensate stimulates monocytes to express toll-like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule 1 (ICAM-1), and enhances their adhesion to the endothelium. However, the same effects of cigarette s...

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Bibliographic Details
Main Authors: Hsin-Yu Yeh, Shou-Hung Hung, Su-Chiu Chen, Fei-Ran Guo, Hsien-Liang Huang, Jen-Kuei Peng, Chung-Sheng Lee, Jaw-Shiun Tsai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
peripheral blood mononuclear cells
smoking cessation
smokers
toll-like receptor 4
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.667460/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.667460/full

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