Long-Term Isolation Elicits Depression and Anxiety-Related Behaviors by Reducing Oxytocin-Induced GABAergic Transmission in Central Amygdala

Long-Term Isolation Elicits Depression and Anxiety-Related Behaviors by Reducing Oxytocin-Induced GABAergic Transmission in Central Amygdala

Isolation stress is a major risk factor for neuropsychiatric disorders such as depressive and anxiety disorders. However, the molecular mechanisms underlying isolation-induced neuropsychiatric disorders remain elusive. In the present study, we investigated the subcellular mechanisms by which long-te...

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Bibliographic Details
Main Authors: Rafael T. Han, Young-Beom Kim, Eui-Ho Park, Jin Yong Kim, Changhyeon Ryu, Hye Y. Kim, JaeHee Lee, Kisoo Pahk, Cui Shanyu, Hyun Kim, Seung K. Back, Hee J. Kim, Yang In Kim, Heung S. Na
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
oxytocin
inhibitory synaptic transmission
central amygdala (CeA)
gamma-aminobutyric acid
isolation
depression and anxiety disorders
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00246/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00246/full

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