Depletion of Host Cell Focal Adhesion Kinase Increases the Susceptibility to Invasion by Trypanosoma cruzi Metacyclic Forms

Depletion of Host Cell Focal Adhesion Kinase Increases the Susceptibility to Invasion by Trypanosoma cruzi Metacyclic Forms

Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase (PTK), is implicated in diverse cellular processes, including the regulation of F-actin dynamics. Host cell F-actin rearrangement is critical for invasion of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease. It is...

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Bibliographic Details
Main Authors: Thiago Souza Onofre, João Paulo Ferreira Rodrigues, Nobuko Yoshida
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma cruzi
metacyclic trypomastigote
host cell invasion
focal adhesion kinase
actin cytoskeleton
lysosome distribution
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00231/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00231/full

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