Trial of Amiloride in Type 2 Diabetes With Proteinuria

Renal sodium (Na+) retention and extracellular fluid volume expansion are hallmarks of nephrotic syndrome, which occurs even in the absence of activation of hormones that stimulate renal Na+ transporters. Plasmin-dependent activation of the epithelial Na+ channel has been proposed to have a role in...

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Bibliographic Details
Main Authors: Mark L. Unruh, V. Shane Pankratz, John E. Demko, Evan C. Ray, Rebecca P. Hughey, Thomas R. Kleyman
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Kidney International Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024917301262