Functional Characteristics of Two Human MATE Transporters: Kinetics of Cimetidine Transport and Profiles of Iinhibition by Various Compounds

Purpose. Human multidrug and toxin extrusion protein 1 (hMATE1) and hMATE2-K are organic cation/H+ antiporters that have recently been identified and suggested to be involved in the renal brush border secretion of various organic cations. Information about functional characteristics of them has been...

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Bibliographic Details
Main Authors: Kin-ya Ohta, Katsuhisa Inoue, Tomoya Yasujima, Munenori Ishimaru, Hiroaki Yuasa
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2010-01-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/6653