Modeling protein folding in vivo

Abstract A half century of studying protein folding in vitro and modeling it in silico has not provided us with a reliable computational method to predict the native conformations of proteins de novo, let alone identify the intermediates on their folding pathways. In this Opinion article, we suggest...

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Bibliographic Details
Main Authors: Irina Sorokina, Arcady Mushegian
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Biology Direct
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13062-018-0217-6