The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon

The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon

NCOMMS-19-38235B Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation of distinct functional regions. Here, the authors find that PcG proteins suppress BMP and Wnt signaling in a region-specific manner, allowing for proper Shh expression and development of the ven...

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Main Authors: Hikaru Eto, Yusuke Kishi, Nayuta Yakushiji-Kaminatsui, Hiroki Sugishita, Shun Utsunomiya, Haruhiko Koseki, Yukiko Gotoh
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19556-5
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spelling doaj-ce804acfbc32428c8f42eaeed912e0a02021-05-11T08:05:01ZengNature Publishing GroupNature Communications2041-17232020-11-0111111710.1038/s41467-020-19556-5The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalonHikaru Eto0Yusuke Kishi1Nayuta Yakushiji-Kaminatsui2Hiroki Sugishita3Shun Utsunomiya4Haruhiko Koseki5Yukiko Gotoh6Graduate School of Pharmaceutical Sciences, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoLaboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (RIKEN-IMS)Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (RIKEN-IMS)Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (RIKEN-IMS)Graduate School of Pharmaceutical Sciences, The University of TokyoNCOMMS-19-38235B Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation of distinct functional regions. Here, the authors find that PcG proteins suppress BMP and Wnt signaling in a region-specific manner, allowing for proper Shh expression and development of the ventral telencephalon.https://doi.org/10.1038/s41467-020-19556-5
collection DOAJ
language English
format Article
sources DOAJ
author Hikaru Eto
Yusuke Kishi
Nayuta Yakushiji-Kaminatsui
Hiroki Sugishita
Shun Utsunomiya
Haruhiko Koseki
Yukiko Gotoh
spellingShingle Hikaru Eto
Yusuke Kishi
Nayuta Yakushiji-Kaminatsui
Hiroki Sugishita
Shun Utsunomiya
Haruhiko Koseki
Yukiko Gotoh
The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon
Nature Communications
author_facet Hikaru Eto
Yusuke Kishi
Nayuta Yakushiji-Kaminatsui
Hiroki Sugishita
Shun Utsunomiya
Haruhiko Koseki
Yukiko Gotoh
author_sort Hikaru Eto
title The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon
title_short The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon
title_full The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon
title_fullStr The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon
title_full_unstemmed The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon
title_sort polycomb group protein ring1 regulates dorsoventral patterning of the mouse telencephalon
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description NCOMMS-19-38235B Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation of distinct functional regions. Here, the authors find that PcG proteins suppress BMP and Wnt signaling in a region-specific manner, allowing for proper Shh expression and development of the ventral telencephalon.
url https://doi.org/10.1038/s41467-020-19556-5
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