RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8+ T cell immune responses. Here, we show that this process is regulated by E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediated mechanism for regu...

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Bibliographic Details
Main Authors: Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, Marnie E Blewitt, William R Heath, Ken Shortman, Anthony W Purcell, Nicos A Nicola, Jian-Guo Zhang, Mireille H Lahoud
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
dendritic cells
DAMP recognition
E3 ubiquitin ligase
ubiquitination
antigen presentation
Online Access:https://elifesciences.org/articles/63452

Internet

https://elifesciences.org/articles/63452

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