Impact of chromosomal rearrangement upon DNA methylation patterns in leukemia

Impact of chromosomal rearrangement upon DNA methylation patterns in leukemia

Genomic instability, including genetic mutations and chromosomal rearrangements, can lead to cancer development. Aberrant DNA methylation occurs commonly in cancer cells. The aim of this study is to determine the effects of a specific chromosomal lesion the BCR-ABL translocation t(9:22), in establis...

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Bibliographic Details
Main Authors: Byun Hyang-Min, Eshaghian Shahrooz, Douer Dan, Trent Jonathen, Garcia-Manero Guillermo, Bhatia Ravi, Siegmund Kim, Yang Allen S.
Format: Article
Language:English
Published: De Gruyter 2017-05-01
Series:Open Medicine
Subjects:
dna methylation
chronic myelogenous leukemia
philadelphia chromosome
acute promyelocytic leukemia
acute lymphoblastic leukemia
gastrointestinal stromal tumor
5-azacytidine
Online Access:https://doi.org/10.1515/med-2017-0014

Internet

https://doi.org/10.1515/med-2017-0014

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