Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

<p>Abstract</p> <p>Background</p> <p>TAK733 is a novel allosteric, non-ATP-binding, inhibitor of the BRAF substrates MEK-1/2.</p> <p>Methods</p> <p>The growth inhibitory effects of TAK733 were assessed in a panel of 27 cutaneous and five uveal me...

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Bibliographic Details
Main Authors: von Euw Erika, Atefi Mohammad, Attar Narsis, Chu Connie, Zachariah Sybil, Burgess Barry L, Mok Stephen, Ng Charles, Wong Deborah JL, Chmielowski Bartosz, Lichter David I, Koya Richard C, McCannel Tara A, Izmailova Elena, Ribas Antoni
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Molecular Cancer
Subjects:
Melanoma
MEK inhibitor
BRAF mutation
Oncogenes
MAPK signaling
Online Access:http://www.molecular-cancer.com/content/11/1/22

Internet

http://www.molecular-cancer.com/content/11/1/22

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