Bile Acids Elevated in Chronic Periaortitis Could Activate Farnesoid-X-Receptor to Suppress IL-6 Production by Macrophages

Bile Acids Elevated in Chronic Periaortitis Could Activate Farnesoid-X-Receptor to Suppress IL-6 Production by Macrophages

Chronic periaortitis (CP) is a rare autoimmune disease without effective treatment. By analyzing the serum bile acid spectrum in 28 CP patients with the ultra-performance liquid chromatography-tandem mass spectrometry, we found that the bile acids were significantly altered in CP patients, with sign...

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Bibliographic Details
Main Authors: Shan Cao, Xinyu Meng, Yixuan Li, Li Sun, Lindi Jiang, Hanqing Xuan, Xiaoxiang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
bile acid
farnesoid-x-receptor
IL-6
chronic periaortitis
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.632864/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.632864/full

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