The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage.

The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage.

ESAT-6, an abundantly secreted protein of Mycobacterium tuberculosis (M. tuberculosis) is an important virulence factor, inactivation of which leads to reduced virulence of M. tuberculosis. ESAT-6 alone, or in complex with its chaperone CFP-10 (ESAT-6:CFP-10), is known to modulate host immune respon...

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Bibliographic Details
Main Authors: Gopalkrishna Sreejit, Asma Ahmed, Nazia Parveen, Vishwanath Jha, Vijaya Lakshmi Valluri, Sudip Ghosh, Sangita Mukhopadhyay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4214792?pdf=render

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http://europepmc.org/articles/PMC4214792?pdf=render

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