The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro

The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro

Sphingosine 1-phosphate (S1P), a bioactive lipid involved in various physiological processes such as cell proliferation and apoptosis, can be irreversibly cleaved by S1P lyase, yielding phosphoethanolamine and (2E)-hexadecenal (2EHD). The latter metabolite, an α,β-unsaturated fatty aldehyde, may be...

Full description

Bibliographic Details
Main Authors: Fabian Schumacher, Corinna Neuber, Hannah Finke, Kai Nieschalke, Jessica Baesler, Erich Gulbins, Burkhard Kleuser
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Journal of Lipid Research
Subjects:
sphingolipids
sphingosine 1-phosphate lyase
liquid chromatography
tandem mass spectrometry
toxicology
fatty aldehyde metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337901

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520337901

Similar Items