Inhibition of microRNA-210 provides neuroprotection in hypoxic–ischemic brain injury in neonatal rats

Inhibition of microRNA-210 provides neuroprotection in hypoxic–ischemic brain injury in neonatal rats

Perinatal hypoxic–ischemic encephalopathy (HIE) is associated with high neonatal mortality and severe long-term neurologic morbidity. Yet the mechanisms of brain injury in infants with HIE remain largely elusive. The present study determined a novel mechanism of microRNA-210 (miR-210) in silencing e...

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Bibliographic Details
Main Authors: Qingyi Ma, Chiranjib Dasgupta, Yong Li, Nikita M. Bajwa, Fuxia Xiong, Benjamin Harding, Richard Hartman, Lubo Zhang
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Neurobiology of Disease
Subjects:
Neonatal hypoxic–ischemic brain injury
MicroRNA-210
Glucocorticoid receptor
Complementary locked nucleic acid (LNA) oligonucleotides
Intranasal delivery
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611630033X

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http://www.sciencedirect.com/science/article/pii/S096999611630033X

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