Genotype-phenotype map characteristics of an in silico heart cell

Genotype-phenotype map characteristics of an in silico heart cell

Understanding the causal chain from genotypic to phenotypic variation is a tremendous challenge with huge implications for personalized medicine. Here we argue that linking computational physiology to genetic concepts, methodology and data provides a new framework for this endeavor. We exemplify thi...

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Bibliographic Details
Main Authors: Jon Olav eVik, Arne Bjørke Gjuvsland, Liren eLi, Kristin eTøndel, Steven eNiederer, Nicolas eSmith, Peter eHunter, Stig William Omholt
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Physiology
Subjects:
Epistasis
causally cohesive genotype-phenotype modeling
cGP heart model
multivariate genotype-to-phenotype map
Penetrance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00106/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00106/full

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