Increased BBB Permeability Enhances Activation of Microglia and Exacerbates Loss of Dendritic Spines After Transient Global Cerebral Ischemia

Increased BBB Permeability Enhances Activation of Microglia and Exacerbates Loss of Dendritic Spines After Transient Global Cerebral Ischemia

Ischemic stroke can induce rapid disruption of blood-brain barrier (BBB). It has been suggested that increased BBB permeability can affect the pathological progression of ischemic tissue. However, the impact of increased BBB permeability on microglial activation and synaptic structures following rep...

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Bibliographic Details
Main Authors: Furong Ju, Yanli Ran, Lirui Zhu, Xiaofeng Cheng, Hao Gao, Xiaoxia Xi, Zhanli Yang, Shengxiang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
BBB
ischemia
reperfusion
microglia
spine
mannitol
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00236/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00236/full

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